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You should not use linezolid if you have untreated or uncontrolled high blood pressurea carcinoid tumoradrenal gland tumoror a severely overactive thyroid.
This antibiotic treats only bacterial infectionsIt will not work for viral infectionssuch as common coldfluUsing any antibiotic when it is not needed can cause it to not work for future infections.
AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.
Avoid coadministration with serotonergic psychiatric drugsegSSRIsSNRIsTCAsMAOIsunless indicated for life-threatening or urgent infectionsegvancomycin-resistant enterococcal infectionsnosocomial pneumoniacomplicated skin and skin structure infections such as methicillin-resistant S aureusdue to increased risk of serotonin syndromelinezolid may increase serotonin CNS levels by MAO-A inhibition If linezolid must be administered to a patient currently taking a serotonergic drugstop serotonergic drug immediately and monitor for CNS toxicityserotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring5 weeks if fluoxetine was takenwhichever comes firstserotonergic psychiatric medications should be stopped at least 2 weeks in advance of linezolid therapyfluoxetine should be stopped at least 5 weeks in advance due to longer half-life.
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