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Patients with psoriasis or rheumatoid arthritis who have preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia, or significant anemia, should not receive methotrexate.

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Information about Methotrexate.

If the patient is vomiting or unable to tolerate oral medicationleucovorin should be added to this regimen at the same dose and schedule as the methotrexate.

The good newsThese side effects can often be short-circuited by taking a folic acid supplementFolic acid is the synthetic form of folateOne study found that RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent.

Dehydrationlow fluid levels in your bodycan worsen the side effects of this drugBe sure to drink enough fluids before taking this drugMethotrexate can cause mouth soresTaking a folic acid supplement may decrease this side effectIt may also help decrease certain kidney or liver side effects from methotrexateYour doctor can tell you more.

Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.

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but he notes that some studies suggest folic acid may make methotrexate less effective.

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