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Patients with a history of VTE or known thrombophilic states have an increased risk of VTEHRT may add to this riskHRT is therefore contraindicated in these patientssee section 4.3Personal or strong family history of thromboembolism or recurrent spontaneous abortion should be investigated in order to exclude a thrombophilic predisposition.
Evidence regarding the risks associated with HRT in the treatment of premature menopause is limitedDue to the low level of absolute risk in younger womenhoweverthe balance of benefits and risks for these women may be more favourable than in older women.
Cases of anaphylaxiswhich develop within minutes to hours after taking orally-administered PREMARIN and require emergency managementhave been reported in the postmarketing settingSkinhivespruritusswollen lips-tongue-faceand either respiratory tractrespiratory compromiseor gastrointestinal tractabdominal painvomitinginvolvement has been noted.
Estrogenseither used alone or with another hormoneprogestinhave rarely caused very serious side effectsDiscuss the risks and benefits of hormone treatment with your doctorEstrogens should not be used to prevent heart disease or dementia.
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