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The recommended starting dosage of PRECOSE is 25 mg given orally three times daily at the startwith the first biteof each main mealHoweversome patients may benefit from more gradual dose titration to minimize gastrointestinal side effectsThis may be achieved by initiating treatment at 25 mg once per day and subsequently increasing the frequency of administration to achieve 25 mg t.i.d.

During treatment initiation and dose titrationsee belowone-hour postprandial plasma glucose may be used to determine the therapeutic response to PRECOSE and identify the minimum effective dose for the patientThereafterglycosylated hemoglobin should be measured at intervals of approximately three monthsThe therapeutic goal should be to decrease both postprandial plasma glucose and glycosylated hemoglobin levels to normal or near normal by using the lowest effective dose of PRECOSEeither as monotherapy or in combination with sulfonylureasinsulin or metformin.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofintestine/bowel problemssuch as inflammatory bowel diseaseblockageulcerskidney problemsliver disease.

The mean steady-state area under the curveAUCand maximum concentrations of acarbose were approximately 1.5 times higher in elderly compared to young volunteershoweverthese differences were not statistically significantPatients with severe renal impairmentClcr Table 1 Mean Placebo-Subtracted Change in HbA1c in Fixed-Dose Monotherapy Studies.

During treatment initiation and dose titrationsee belowone-hour postprandial plasma glucose may be used to determine the therapeutic response to Precose and identify the minimum effective dose for the patientThereafterglycosylated hemoglobin should be measured at intervals of approximately three monthsThe therapeutic goal should be to decrease both postprandial plasma glucose and glycosylated hemoglobin levels to normal or near normal by using the lowest effective dose of Precoseeither as monotherapy or in combination with sulfonylureasinsulin or metformin.

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