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Caution phyenylalanine and tyrosine should not be taken by those using mao inhibitors and should be used with caution in those on thyroid medication synthroid .

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Infants with congenital hypothyroidism appear to be at increased risk for other congenital anomalieswith cardiovascular anomaliespulmonary stenosisatrial septal defectand ventricular septal defectbeing the most common association.

Thyroid hormone synthesis and secretion is regulated by the hypothalamic-pituitary-thyroid axisThyrotropin-releasing hormoneTRHreleased from the hypothalamus stimulates secretion of thyrotropin-stimulating hormoneTSHfrom the anterior pituitaryTSHin turnis the physiologic stimulus for the synthesis and secretion of thyroid hormonesL-thyroxineT 4and L-triiodothyronineT 3by the thyroid glandCirculating serum T 3 and T 4 levels exert a feedback effect on both TRH and TSH secretionWhen serum T 3 and T 4 levels increaseTRH and TSH secretion decreaseWhen thyroid hormone levels decreaseTRH and TSH secretion increase.

Fatigueincreased appetiteweight lossheat intolerancefeverexcessive sweating;

Hair loss may happen in some people in the first few months of using Synthroidlevothyroxine tabletsThis most often goes back to normal.

Occasionallychronic autoimmune thyroiditis may occur in association with other autoimmune disorders such as adrenal insufficiencypernicious anemiaand insulin-dependent diabetes mellitusPatients with concomitant adrenal insufficiency should be treated with replacement glucocorticoids prior to initiation of treatment with levothyroxine sodiumFailure to do so may precipitate an acute adrenal crisis when thyroid hormone therapy is initiateddue to increased metabolic clearance of glucocorticoids by thyroid hormonePatients with diabetes mellitus may require upward adjustments of their antidiabetic therapeutic regimens when treated with levothyroxinesee DRUG INTERACTIONS

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