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This interference leads to poorer promethazine metabolism and a longer elimination half-life.

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Promethazine is used to prevent and treat nausea and vomiting related to certain conditionssuch as before/after surgerymotion sicknessIt is also used to treat allergy symptoms such as rashitchingand runny noseIt may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relieverssuch as meperidinework betterIt may also be used for a short time to treat a runny nose due to the common cold.

Sedating drugs may cause confusion and over-sedation in the elderlyelderly patients generally should be started on low doses of promethazine hydrochloride tablets and observed closely.

Parenteral25 mg IV or IM oncefollowed by close observation for responseThis dose may be repeated within 2 hours if neededOral therapy should be started as soon as feasible if continued medication is required.

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