Chlorpropamide s plasma half-life may be prolonged by zyloprim allopurinol , since zyloprim allopurinol and chlorpropamide may compete for excretion in the renal tubule.
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Allopurinol is an inhibitor of xanthine oxidasea substance in the body that is responsible for the product of uric acidIt is used to prevent goutkidney stonesand kidney damage caused by uric acidIt is also used to reduce the levels of uric acid in the blood that occur because of blood disorders associated with cancer such as leukemias and lymphomas.
The clearance of oxipurinol is increased by uricosuric drugsand as a consequencethe addition of a uricosuric agent reduces to some degree the inhibition of xanthine oxidase by oxipurinol and increases to some degree the urinary excretion of uric acidIn practicethe net effect of such combined therapy may be useful in some patients in achieving minimum serum uric acid levels provided the total urinary uric acid load does not exceed the competence of the patient’s renal function.
You should tell your doctor if you have any of the following conditions before taking allopurinolLiver disease Kidney disease Diabetes Congestive heart failure High blood pressure Are pregnant or breastfeeding Are receiving chemotherapy drugs.
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acetaminophen tylenol or other analgesic painkillers – helps to manage pain nsaids nonsteroidal anti-inflammatory drugs , more specifically indocin indomethacin – helps to control inflammation colchicine – prevents or relieves gout attacks by suppressing inflammation corticosteroids – provokes a quick anti-inflammatory response probenecid benemid, probalan – decreases uric acid blood levels by increasing the excretion of uric acid into the urine colbenemid other brand names are col-probenecid and proben-c – contains probenecid, a uricosuric agent, and colchicine, which has anti-gout properties allopurinol zyloprim – lowers blood uric acid by preventing uric acid production; blocks the conversion of purines to uric acid by xanthine oxidase febuxostat uloric – lowers serum uric acid levels by blocking xanthine oxidase similar to allopurinol losartan cozaar and hyzaar – not specifically a gout medication but it is an angiotensin ii receptor antagonist, antihypertensive drug which may help control uric acid levels.