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In a placebo-controlled trial in normal volunteers, administration of zoloft for 22 days including 200 mg day for the final 13 days caused a statistically significant 16 decrease from baseline in the clearance of tolbutamide following an intravenous 1000 mg dose.

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To make sure you can safely take sertralinetell your doctor if you have any of these other conditions:

False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking ZOLOFTThis finding is due to lack of specificity of the screening testsFalse-positive test results may be expected for several days following discontinuation of ZOLOFTConfirmatory testssuch as gas chromatography/mass spectrometrywill help distinguish ZOLOFT from benzodiazepinesSee DRUG INTERACTIONS

Birth defects and fetal harm are possible when Zoloft is taken during pregnancybut the risk is very lowThe drug may be transferred via breast milkThereforetalk to your doctor about the risks and benefits if you are pregnantplanning to become pregnantor are nursing before you take Zoloft.

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