The pharmacokinetics of metaxalone have been evaluated in healthy adult volunteers after single dose administration of skelaxin under fasted and fed conditions at doses ranging from 400 mg to 800 mg.
Information about Skelaxin.
SKELAXINmetaxaloneis indicated as an adjunct to restphysical therapyand other measures for the relief of discomforts associated with acutepainful musculoskeletal conditionsThe mode of action of this drug has not been clearly identifiedbut may be related to its sedative propertiesMetaxalone does not directly relax tense skeletal muscles in man.
Take this medication by mouth with or without food as directed by your doctorusually 3 or 4 times a dayIf you take this medication after a high-fat meal and experience side effectsit may be best to take this drug on an empty stomach or after a light meal.
It is not known whether this medicine will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnant.
Serotonin syndromeSSwhich is potentially life-threateninghas been reported with metaxalone useThese reports generally occurred when metaxalone was used concomitantly with serotonergic drugssuch as tramadol or selective serotonin reuptake inhibitorsSSRIsor when metaxalone was used at doses higher than the recommended dosesee DRUG INTERACTIONS and OVERDOSAGESigns of SS may include clonusagitationdiaphoresistremorhyperreflexiahypertoniaand temperature elevation.
The mechanism of action of metaxalone in humans has not been establishedbut may be due to general central nervous system depression.
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this review investigates the efficacy, side effects, and safety of three commonly prescribed skeletal muscle relaxants metaxalone skelaxin , cyclobenzaprine flexeril , and carisoprodol soma .