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Do not crush or chew a delayed-release capsuleHowever to make swallowing easieryou may open the capsule and sprinkle the medicine into a spoonful of pudding or applesauceSwallow right away without chewingDo not save the mixture for later use.

Esomeprazole was negative in the Ames mutation testin the in vivo rat bone marrow cell chromosome aberration testand the in vivo mouse micronucleus testEsomeprazolehoweverwas positive in the in vitro human lymphocyte chromosome aberration testOmeprazole was positive in the in vitro human lymphocyte chromosome aberration testthe in vivo mouse bone marrow cell chromosome aberration testand the in vivo mouse micronucleus test.

Ask a doctor before using this medicine if you are pregnant or breast-feeding.

Hypersensitivity Reactionssee CONTRAINDICATIONSAcute Interstitial Nephritissee WARNINGS AND PRECAUTIONSClostridium difficile Associated Diarrheasee WARNINGS AND PRECAUTIONSBone Fracturesee WARNINGS AND PRECAUTIONSCutaneous and Systemic Lupus Erythematosussee WARNINGS AND PRECAUTIONSCyanocobalaminVitamin B-12Deficiencysee WARNINGS AND PRECAUTIONSHypomagnesemiasee WARNINGS AND PRECAUTIONSDrug Interactions Advise patients to let you know if they are takingor begin takingother medicationsbecause NEXIUM can interfere with antiretroviral drugs and drugs that are affected by gastric pH changessee DRUG INTERACTIONS

Use this medicine for the full prescribed length of timeeven if your symptoms quickly improve.

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nexium, aggressively marketed as the little purple pill, is the most popular of the class, and generated an estimated 6 billion in annual sales before generic and over-the-counter brands became available.

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