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For patients with intravascular volume-depletione.gthose treated with high-dose diureticsa starting dose of 25 mg once daily should be consideredsee section 4.4

Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusivehowever a small increase in risk cannot be excludedWhilst there is no controlled epidemiological data on the risk with Angiotensin II Receptor InhibitorsAIIRAssimilar risks may exist for this class of medicinal productsUnless continued AIIRA therapy is considered essentialpatients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancyWhen pregnancy is diagnosedtreatment with losartan should be stopped immediately andif appropriatealternative therapy should be started.

Following oral administrationlosartan is well absorbed and undergoes first-pass metabolismforming an active carboxylic acid metabolite and other inactive metabolitesThe systemic bioavailability of losartan tablets is approximately 33Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4 hoursrespectively.

Reduction in the risk of stroke in hypertensive patients with left ventricular hypertrophy documented by ECG.

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also, when taking cozaar losartan , avoid potassium supplements or salt substitutes unless your doctor has instructed you to.

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