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The antiemetic properties of metoclopramide appear to be a result of its antagonism of central and peripheral dopamine receptorsDopamine produces nausea and vomiting by stimulation of the medullary chemoreceptor trigger zoneCTZand metoclopramide blocks stimulation of the CTZ by agents like ldopa or apomorphine which are known to increase dopamine levels or to possess dopamine-like effectsMetoclopramide also abolishes the slowing of gastric emptying caused by apomorphine.
Hypotensionhypertensionsupraventricular tachycardiabradycardiafluid retentionacute congestive heart failure and possible atrioventricularAVblocksee CONTRAINDICATIONS and PRECAUTIONS
A few cases of rashurticariaor bronchospasmespecially in patients with a history of asthmaRarelyangioneurotic edemaincluding glossal or laryngeal edema.
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