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One great advantage of this approach is the ease with which varying functionality can be added throughout the structure, particularly substituents at c5 x , c6 r , c7 y , c9 z , and even an extra e ring; a great many analogues have been made, and some of these combine strong antibacterial activity with activity against strains resistant to first- and second-generation tetracycline antibiotics myers et al.

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Tetracycline may also be used for other purposes not listed in this medication guide.

The tetracyclines are broad-spectrum antibiotics with similar antimicrobial featuresbut they differ somewhat from one another in terms of their spectra and pharmacokinetic disposition.

Many antibiotics are readily metabolized to more polar productsas conjugates;

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in each case the target antibiotic resistance phenotype was lost, tetracycline resistance in the case of pute tetm and chloramphenicol resistance in the case of pute catq, generating b.

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