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Colchicine and indinavir should not be coadministered to patients with hepatic or renal impairment.

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The chemical name for indinavir sulfate is1(1S,2R5(S2,3,5-trideoxy-N2,3-dihydro-2-hydroxy-1Hinden-

It may also be necessary to avoid drugs that do not affect indinavir drug levelsbut cause similar side effects.

Clinically significant adverse reactionspotentially leading to severelife-threateningor fatal events from greater exposures of concomitant medicationsClinically significant adverse reactions from greater exposures of CRIXIVANLoss of therapeutic effect of CRIXIVAN and possible development of resistance.

CRIXIVAN is contraindicated in patients with clinically significant hypersensitivity to any of its components.

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