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Some products that may interact with this drug includeother alpha blocker drugssuch as prazosintamsulosin

If therapy is discontinued for several daysinitiate dose at 1 mg qDay and titrate using initial dosing regimen.

Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

Cardiovascular SystemCerebrovascular accidentsdizziness posturalmyocardial infarction.

Avoid use for hypertensionhigh risk of orthostatic hypotensionBeers criteriaif usedlower initial dosages and gradual adjustments are recommended.

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