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XELODA dose modification scheme as described belowsee Table 2is recommended for the management of adverse reactions.

Figure 5 Kaplan-Meier Estimates of Survival XELODA and Docetaxel vs Docetaxel.

The efficacy endpoints for the two phase 3 trials are shown in Table 14 and Table 15.

Table 19 Response Rates in Doubly-Resistant Patients Single-Arm Breast Cancer Trial.

The cardiotoxicity observed with XELODA includes myocardial infarction/ischemiaanginadysrhythmiascardiac arrestcardiac failuresudden deathelectrocardiographic changesand cardiomyopathyThese adverse reactions may be more common in patients with a prior history of coronary artery disease.

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